CD163 - TRAIN project



Increased concentrations of the soluble mannose receptor in serum from patients with pneumococcal bacteraemia, and prediction of survival.

Rødgaard-Hansen S, Rafique A, Weis N, Wejse C, Nielsen H, Pedersen SS, Møller HJ, Kronborg G.

Infect Dis (Lond). 2015 Apr;47(4):203-8. doi: 10.3109/00365548.2014.984321. Epub 2015 Feb 4.


The macrophage activation marker sCD163 is independently associated with NAFLD severity in morbid obesity and reduced by bariatric surgery.

Kazankov K, Tordjman J, Møller HJ, Vilstrup H, Poitou C, Bedossa P, Bouillot JL, Clement K, Grønbaek H.

J Gastroenterol Hepatol. 2015 Mar 13. doi: 10.1111/jgh.12943. [Epub ahead of print]


Visceral obesity is associated with increased soluble CD163 concentration in men with type 2 diabetes mellitus.

Sørensen LP, Parkner T, Søndergaard E, Bibby BM, Møller HJ, Nielsen S.

Endocr Connect. 2015 Mar;4(1):27-36.


Biodistribution and PET imaging of a novel [68Ga]-anti-CD163-antibody conjugate in rats with collagen-induced arthritis and in controls..

Eichendorff S, Svendsen P, Bender D, Keiding S, Christensen EI, Deleuran B, Moestrup SK.

Mol Imaging Biol. 2015 Feb;17(1):87-93.


Intrahepatic fat content correlates with soluble CD163 in relation to weight loss induced by Roux-en-Y gastric bypass.

Fjeldborg K, Pedersen SB, Møller HJ, Rask P, Danielsen AV, Stødkilde-Jørgensen H, Richelsen B.

Obesity (Silver Spring). 2015 Jan;23(1):154-61.


Soluble CD163 levels are elevated in cerebrospinal fluid and serum in people with Type 2 diabetes mellitus and are associated with impaired peripheral nerve function.

Kallestrup M, Møller HJ, Tankisi H, Andersen H.

Diabet Med. 2015 Jan;32(1):54-61.




Hepatic macrophage activation and the LPS pathway in patients with alcoholic hepatitis: a prospective cohort study.

Sandahl TD, Grønbaek H, Møller HJ, Støy S, Thomsen KL, Dige AK, Agnholt J, Hamilton-Dutoit S, Thiel S, Vilstrup H.

Am J Gastroenterol. 2014 Nov;109(11):1749-56.


Regulation of CD163 mRNA and soluble CD163 protein in human adipose tissue in vitro.

Fjeldborg K, Møller HJ, Richelsen B, Pedersen SB.

J Mol Endocrinol. 2014 Oct;53(2):227-35.


The macrophage activation marker sCD163 is associated with changes in NAFLD and metabolic profile during lifestyle intervention in obese children.

Kazankov K, Møller HJ, Lange A, Birkebaek NH, Holland-Fischer P, Solvig J, Hørlyck A, Kristensen K, Rittig S, Handberg A, Vilstrup H, Grønbaek H.

Pediatr Obes. 2014 Jul 30. doi: 10.1111/ijpo.252.


Soluble CD163 correlates with the fibrosis models APRI and FIB-4 and independently predicts liver fibrosis in chronic HBV and HCV infection.

Kazankov K, Møller HJ, Bibby BM, Vilstrup H, George J, Grønbæk H.

Hepatology. 2014 Jul 12. doi: 10.1002/hep.27302.


Human adipose tissue macrophages are enhanced but changed to an anti-inflammatory profile in obesity.

Fjeldborg K, Pedersen SB, Møller HJ, Christiansen T, Bennetzen M, Richelsen B.

J Immunol Res. 2014;2014:309548.


Monocyte expression and soluble levels of the haemoglobin receptor (CD163/sCD163) and the mannose receptor (MR/sMR) in septic and critically ill non-septic ICU patients.

Kjærgaard AG, Rødgaard-Hansen S, Dige A, Krog J, Møller HJ, Tønnesen E.

PLoS One. 2014 Mar 17;9(3):e92331.


Soluble CD163, a macrophage activation marker, is independently associated with fibrosis in patients with chronic viral hepatitis B and C.

Kazankov K, Barrera F, Møller HJ, Bibby BM, Vilstrup H, George J, Grønbaek H.

Hepatology. 2014 Aug;60(2):521-30.


Macrophage-related serum biomarkers soluble CD163 (sCD163) and soluble mannose receptor (sMR) to differentiate mild liver fibrosis from cirrhosis in patients with chronic hepatitis C: a pilot study.

Andersen ES, Rødgaard-Hansen S, Moessner B, Christensen PB, Møller HJ, Weis N.

Eur J Clin Microbiol Infect Dis. 2014 Jan;33(1):117-22.




The Macrophage-Specific Serum Marker, Soluble CD163, Is Increased in Obesity and Reduced After Dietary-Induced Weight Loss

Fjeldborg K, Christiansen T, Bennetzen M, Møller HJ, Pedersen SB, Richelsen B

Obesity. 2013 Dec;21(12)


The macrophage low-grade inflammation marker sCD163 is modulated by exogenous sex steroids.

Thomsen HH, Møller HJ, Trolle C, Groth KA, Skakkebæk A, Bojesen A, Høst C, Gravholt CH.

Endocr Connect. 2013 Nov 8;2(4):216-24


A soluble form of the macrophage-related mannose receptor (MR/CD206) is present in human serum and elevated in critical illness.

Rødgaard-Hansen S, Rafique A, Christensen PA, Maniecki MB, Sandahl TD, Nexø E, Møller HJ.

Clin Chem Lab Med. 2013 Oct 11:1-9


Targeting dexamethasone to macrophages in a porcine endotoxemic model.

Granfeldt A, Hvas CL, Graversen JH, Christensen PA, Petersen MD, Anton G, Svendsen P, Sølling C, Etzerodt A, Tønnesen E, Moestrup SK, Møller HJ.

Crit Care Med. 2013 Nov;41(11):e309-18


Hepatic macrophage activation predicts clinical decompensation in chronic liver disease.

Rode A, Nicoll A, Møller HJ, Lim L, Angus PW, Kronborg I, Arachchi N, Gorelik A, Liew D, Kazankov K, Vilstrup H, Grønbæk H.

Gut. 2013 Aug;62(8):1231-2


CD163 and inflammation: biological, diagnostic, and therapeutic aspects.

Etzerodt A, Moestrup SK.

Antioxid Redox Signal. 2013 Jun 10;18(17):2352-63.




Soluble CD163, a marker of Kupffer cell activation, is related to portal hypertension in patients with liver cirrhosis.

Grønbaek H, Sandahl TD, Mortensen C, Vilstrup H, Møller HJ, Møller S.

Aliment Pharmacol Ther. 2012 Jul;36(2):173-80


Soluble CD163: a biomarker linking macrophages and insulin resistance.

Parkner T, Sørensen LP, Nielsen AR, Fischer CP, Bibby BM, Nielsen S, Pedersen BK, Møller HJ.

Diabetologia. 2012 Jun;55(6):1856-62


Soluble CD163.

Møller HJ.

Scand J Clin Lab Invest. 2012 Feb;72(1):1-13